Sarazan, R. D.: search on Z-Library

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1

The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Chiang, Alan Y., Guth, Brian D., Pugsley, Michael K., Foley, C. Michael, Doyle, Jennifer M., Engwall, Michael J., Koerner, John E., Parish, Stanley T., Dustan Sarazan, R.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 833 KB

english, 2018

2

Effects of Antipsychotic Drugs onIto,INa,Isus,IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

William J. Crumb, Sean Ekins, R. Dustan Sarazan, James H. Wikel, Steven A. Wrighton, Christopher Carlson, Charles M. Beasley

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 617 KB

english, 2006

3

Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil

R. Dustan Sarazan, William J. Crumb Jr., Charles M. Beasley Jr., Jeffrey T. Emmick, Kenneth M. Ferguson, Christine A. Strnat, Peter J. Sausen

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 141 KB

english, 2004

4

Cardiovascular pressure measurement in safety assessment studies: Technology requirements and potential errors

Sarazan, R. Dustan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 1.95 MB

english, 2014

5

A call for more integrated cardiovascular safety assessment

S.D. Pettit, B. Berridge, R.D. Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 105 KB

english, 2010

6

Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studies

R. Dustan Sarazan, John P. Kroehle, Bradley W. Main

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 1.09 MB

english, 2012

7

Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs

Andrea Z. Mitchell, Carrie McMahon, Tom W. Beck, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 1.32 MB

english, 2010

8

Cardiovascular Function in Nonclinical Drug Safety Assessment: Current Issues and Opportunities

Sarazan, R. D., Mittelstadt, S., Guth, B., Koerner, J., Zhang, J., Pettit, S.

Journal:

International Journal of Toxicology

Year:

2011

Language:

english

File:

PDF, 367 KB

english, 2011

9

Left thoracotomy surgical approach for chronic instrumentation in dogs and monkeys providing high-quality electrocardiogram signals

Tracy A. Henriques, Thomas W. Beck, Christopher L. Douglas, Hilton M. Jones, John J. Kremer, Paul J. Kruzich, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

10

Comparison of direct and ultrasound-derived pulse wave velocity measurement in conscious and anesthetized Wistar rats

Regan, Hillary K., Regan, Christopher P., Messina, Eric, Fanelli, Patrick, Bogie, Heather, Dustan Sarazan, R., Sannajust, Frederick

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2015

Language:

english

File:

PDF, 54 KB

english, 2015

11

Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

Berridge, Brian R., Schultze, A. Eric, Heyen, Jon R., Searfoss, George H., Sarazan, R. Dustan

Journal:

Year:

2016

Language:

english

File:

PDF, 737 KB

english, 2016

12

Evaluation of blood pressure measurement using a miniature blood pressure transmitter with jacketed external telemetry in cynomolgus monkeys

Carrie McMahon, Andrea Z. Mitchell, Jessica L. Klein, Angela C. Jenkins, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 1.29 MB

english, 2010

13

Standing on the shoulders of giants: Dean Franklin and his remarkable contributions to physiological measurements in animals

Sarazan, R. D., Schweitz, K. T. R.

Journal:

AJP Advances in Physiology Education

Year:

2009

Language:

english

File:

PDF, 4.85 MB

english, 2009

14

Pharmacokinetic/pharmacodynamic (PK/PD) modeling for the respiratory effect of aminophylline in rats

Sun Ku Lee, Angela C. Jenkins, Kathy Hoffman, Magdy Abdelhameed, T.W. Beck, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

15

Cardiovascular effects of detomidine, a new α2-adrenoceptor agonist, in the conscious pony

R. D. SARAZAN, W. A. STARKE, G. F. KRAUSE, H. E. GARNER

Journal:

Journal of Veterinary Pharmacology and Therapeutics

Year:

1989

Language:

english

File:

PDF, 672 KB

english, 1989

16

Opportunities to meet clinical cardio-oncology needs with new approaches to non-clinical safety assessment

Berridge, Brian R., Pettit, Syril D., Sarazan, R. Dustan

Journal:

Progress in Pediatric Cardiology

Year:

2014

Language:

english

File:

PDF, 153 KB

english, 2014

17

A refined surgical technique for telemetry in group housed macaques (M. fascicularis)

Luft, J., Sternberg, J., Fine, M., Sarazan, D.

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 76 KB

english, 2013

18

Chronically Instrumented Conscious Dog Model in Cardiovascular Toxicology Studies

Sarazan, R. Dustan

Journal:

Toxicology Mechanisms and Methods

Year:

1993

Language:

english

File:

PDF, 1.72 MB

english, 1993

19

Comparison of ECG signals and arrhythmia detection using jacketed external telemetry and implanted telemetry in monkeys

John J. Kremer, C. Michael Foley, Zhuzai Xiang, Elizabeth Lemke, R. Dustan Sarazan, Mark A. Osinski, Thomas W. Beck

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2011

Language:

english

File:

PDF, 55 KB

english, 2011

20

Health and environmental sciences institute integrated strategies working group: Update on the evaluation of drug-induced changes in the cardiac inotropy in dogs

Engwall, Michael J., Walisser, Jacqueline A., Saul, Jim, Dustan Sarazan, R., Guth, Brian, Market, Michael, Skinner, Matthew, Guillon, Jean-Michel, Ottinger, Sean, Heyen, Jonathan R., Cools, Frank, Hof

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 49 KB

english, 2014

21

A public–private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

Pierson, Jennifer B., Berridge, Brian R., Brooks, Marjory B., Dreher, Kevin, Koerner, John, Schultze, A. Eric, Sarazan, R. Dustan, Valentin, Jean-Pierre, Vargas, Hugo M., Pettit, Syril D.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 524 KB

english, 2013

22

A HESI collaborative initiative towards a more integrated approach to cardiovascular safety assessment

Dustan R. Sarazan, Syril D. Pettit, Brian R. Berridge

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 67 KB

english, 2010

23

Statistical power analysis for hemodynamic cardiovascular safety pharmacology studies in beagle dogs

Alan Y. Chiang, Wendell C. Smith, Bradley W. Main, R.Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2004

Language:

english

File:

PDF, 324 KB

english, 2004

24

Left thoracotomy surgical approach for chronic instrumentation in dogs providing high quality left ventricular pressure, aortic pressure and cardiac electrocardiogram signals

Tracy A. Henriques, Thomas D. Cleven, Michael Taschwer, Thomas W. Beck, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 50 KB

english, 2010

25

Pimobendan, etilefrine, moxifloxacin, and esketamine as reference compounds to validate the DSI Physiotel Digital System in cynomolgus monkeys

Niehoff, Marc, Sternberg, Jan, Niggemann, Birgit, Sarazan, Dusty

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 46 KB

english, 2014

26

Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation

Rossman, Eric I., Cools, Frank, Cordes, Jason S., Dhuyvetter, Deborah, Doyle, Jennifer, Friedrichs, Gregory S., Guth, Brian, Parish, Stanley T., Pugsley, Michael K., Dustan Sarazan, R.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 69 KB

english, 2018

27

Equine ocular parasites: A review

C. P. MOORE, R. D. SARAZAN, R. D. WHITLEY, W. F. JACKSON

Journal:

Equine Veterinary Journal

Year:

1983

Language:

english

File:

PDF, 3.48 MB

english, 1983

28

Head-out rat plethysmography with intravenous infusion of test articles: Development and validation of a new method

Angela C. Jenkins, Mark A. Osinski, C. Michael Foley, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 55 KB

english, 2008

29

A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animals

John Kroehle, Becky Volovsek, Dan Singer, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

30

Disuse inhibition of newly functional coronary collateral circulation in ponies

Rugh, K. S., Ross, C. R., Sarazan, R. D., Boatwright, R. B., Williams, D. O., Garner, H. E., Griggs, D. M.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1992

Language:

english

File:

PDF, 1.56 MB

english, 1992

31

Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs

B. W. MAIN, J. R. MEANS, L. E. RINKEMA, W. C. SMITH, R. D. SARAZAN

Journal:

Journal of Veterinary Pharmacology and Therapeutics

Year:

1996

Language:

english

File:

PDF, 675 KB

english, 1996

32

High definition oscillometry (HDO): A novel technique for non-invasive blood pressure measurements in beagle dogs

Andrea Z. Mitchell, Carrie McMahon, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

33

Validation of a Digital Data Acquisition and Analysis System in a Cardiovascular Toxicology Laboratory

Sarazan, R. Dustan

Journal:

Toxicology Mechanisms and Methods

Year:

1994

Language:

english

File:

PDF, 1.17 MB

english, 1994

34

VALIDATION OF A DIGITAL DATA ACQUISITION AND ANALYSIS SYSTEM

A. Jenkins, R.D. Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 55 KB

english, 2007

35

Equine coronary hemodynamics during brief coronary occlusions at three levels of collateral function

Williams, D. O., Boatwright, R. B., Rugh, K. S., Ross, C. R., Sarazan, R. D., Garner, H. E., Griggs, D. M.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1996

Language:

english

File:

PDF, 3.10 MB

english, 1996

36

Noninvasive ECG telemetry using Bluetooth® technology in concious nonhuman primates in a toxicology study setting

Angela C. Jenkins, Andrea Mitchell, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 70 KB

english, 2008

37

Demonstration of simultaneous automated blood sample collection and recording of radiotelemetered physiologic measurements in caged unrestrained cynomolgus macaques

Kruzich, P.J., Hopper, L.D., Kurtz, S.L., Swaab, M., Singer, D., Sarazan, R.D.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 43 KB

english, 2014

38

Moxifloxacin in conscious dogs with epicardial ECG leads and semi-automated scoring

Christopher L. Douglas, Thomas W. Beck, Jacqueline A. Walisser, C. Michael Foley, John J. Kremer, R. Dustan Sarazan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 50 KB

english, 2010

39

HESI Cardic Safety Committee: Prospective studies to evaluate the sensitivity of animal models to predict effects of human drugs on cardiac contractility

Guth, Brian, Sarazan, R. Dustan, Berridge, Brian, Pierson, Jennifer, Pettit, Syril, Mittelstadt, Scott, Rossman, Eric I.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2013

Language:

english

File:

PDF, 71 KB

english, 2013

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